Clinical endocrinology

Clinical Endocrinology & Metabolism

A surgically removed pituitary adenomas, approximately 30-35% appear to be silent, unassociated with clinical or biochemical evidence of any anterior pituitary hormone excess (1, 2). However, with routine immunocytochemical staining of the pituitary tumor tissue, immunoreactive hormone material can be demonstrated in a substantial number of these seemingly nonfunctioning tumors (2). Clinically ...

Progress in Clinical Endocrinology

in such a way as to test the hypothesis; the observations gained from the experiment are incorporated in a new hypothesis. Bernard recognized that the success or failure of the procedure was in great part dependent upon the attitude of the investigator and demanded open-mindedness, doubt, and unprejudiced observation. Today we recognize that investigation of the properties of living material ca...

Clinical Endocrinology Hyperthyroidism

many as a single entity. The aetiology of the disease remains obscure. It has, however, been clearly established that thyroid-stimulating hormone (TSH) is not responsible for the excessive thyroid activity. An abnormal thyroid stimulator (known as long-acting thyroid stimulator, or LATS), which is both chemically and immunologically distinct from TSH, is found in the serum of many patients with...

Small Animal Clinical Endocrinology

Clinical Medicine: Endocrinology and Diabetes

Objectives: To investigate the role of insulin resistance (IR) and insulin plasma levels (IRI) in patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Methods: We recruited the following patients: 125 with HCC, 128 with liver cirrhosis (LC) and 133 with chronic hepatitis C (CHC). IR was assessed by the HOMA-IR method. To define IR and hyperinsulinemia we selected as a c...